ザイツェフ配向 vs ホフマン配向：脱離基が決めるアルケンの行方

Leaving Group Effects in Elimination: Zaitsev vs Hofmann Orientation in Industry and Research

Abstract

In elimination reactions, the position of the resulting double bond can follow either Zaitsev or Hofmann orientation. Zaitsev’s rule favors the more substituted, thermodynamically stable alkene, whereas Hofmann’s rule gives the less substituted alkene due to steric or leaving-group effects. This article explains these orientations in simple term…