分子構造からTLCのRf値を推定する方法

How to Estimate TLC Rf Values from Molecular Structure

Abstract: Thin-layer chromatography (TLC) on silica gel is a ubiquitous method for assessing compound polarity and guiding purification in organic synthesis. This article discusses practical approaches to estimate TLC retention factors (Rf) based on molecular structure, focusing on simple heuristics and functional group contributions reported in the lit…